Abstract
Effective prevention and management of diabetes relies on maintaining a normal blood glucose level, thus avoiding abnormal events such as hyperglycemia and hypoglycemia. Predicting anomalous events beforehand can potentially help patients and caregivers intervene to prevent such events through modifiable behaviors such as exercise, diet, and medication. Although Continuous Glucose Monitor (CGM) sensors have been used to monitor and forecast blood glucose level, current research lacks a computational approach that recommends a behavioral intervention to bring the glucose level to a normal range. To address this shortcoming, we present GlySim, a CGM simulator that uses multimodal data to not only forecast future glucose readings but also enable a user to examine the impacts of behavior change on glucose response in advance. GlySim creates opportunities for change in food consumption, medication, and physical activity to avoid dysglycemia by pinpointing factors that cause anomalous events using Grad-CAM (Gradient-weighted Class Activation Mapping) and allowing users to observe how adjusting a behavioral factor changes glucose trajectories. We validate GlySim on a dataset of 10 patients with type 1 diabetes and achieve an overall mean absolute error (MAE) as low as 16.5 mg/dl in simulating glycemic response. Furthermore, Glysim detects hyperglycemic events with 0.89 average precision.
Asiful Arefeen
Graduate Research Assistant
I am a PhD student at Arizona State University (ASU). I am working under the supervision of Professor Hassan Ghasemzadeh at the Embedded Machine Intelligence Lab (EMIL). My research topics include machine learning, health monitoring system development and mobile health. I received my B.S. in Electrical and Electronic Engineering from Bangladesh University of Engineering & Technology (BUET) in 2019.
Hassan Ghasemzadeh
Director
Hassan Ghasemzadeh is an Associate Professor of Biomedical Informatics at Arizona State University (ASU) and a Computer Science Adjunct Faculty at Washington State University (WSU).